Bifidobacterium Pseudolongum Suppresses Colorectal Cancer
Welcome to this week’s journal spotlight from EndoCollab. A new Gut study reveals that a brief fasting-mimicking diet selectively enriches Bifidobacterium pseudolongum, supercharging tissue-resident memory CD8⁺ T cells with L-arginine and throttling colorectal-tumour growth.
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Fasting-mimicking diet (FMD) boosts the antitumour immune response in patients with colorectal cancer (CRC).
Bifidobacterium pseudolongum contributes to the FMD antitumour effects in CRC by producing L-arginine. This promotes CD8+ T-cell differentiation into memory cells. B. pseudolongum administration is a potential CRC therapeutic strategy.
